Discovery of VU0467485/AZ13713945: An M(4) PAM Evaluated as a Preclinical Candidate for the Treatment of Schizophrenia

[Image: see text] Herein, we report the structure–activity relationships within a series of potent, selective, and orally bioavailable muscarinic acetylcholine receptor 4 (M(4)) positive allosteric modulators (PAMs). Compound 6c (VU0467485) possesses robust in vitro M(4) PAM potency across species a...

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Detalhes bibliográficos
Publicado no:ACS Med Chem Lett
Main Authors: Wood, Michael R., Noetzel, Meredith J., Melancon, Bruce J., Poslusney, Michael S., Nance, Kellie D., Hurtado, Miguel A., Luscombe, Vincent B., Weiner, Rebecca L., Rodriguez, Alice L., Lamsal, Atin, Chang, Sichen, Bubser, Michael, Blobaum, Anna L., Engers, Darren W., Niswender, Colleen M., Jones, Carrie K., Brandon, Nicholas J., Wood, Michael W., Duggan, Mark E., Conn, P. Jeffrey, Bridges, Thomas M., Lindsley, Craig W.
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2016
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5304297/
https://ncbi.nlm.nih.gov/pubmed/28197318
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.6b00461
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