Challenges in the development of an M(4) PAM preclinical candidate: The discovery, SAR, and biological characterization of a series of azetidine-derived tertiary amides

相似書籍

• Corrigendum to “Challenges in the development of an M(4) PAM preclinical candidate: The discovery, SAR, and biological characterization of a series of azetidine-derived tertiary amides” [Bioorg. Med. Chem. Lett. 27(23) (2017) 5179-5184]
  由: Tarr, James C., et al.
  出版: (2018)
• Challenges in the development of an M4 PAM preclinical candidate: The discovery, SAR, and in vivo characterization of a series of 3-aminoazetidine-derived amides
  由: Tarr, James C., et al.
  出版: (2017)
• Challenges in the development of an M(4) PAM in vivo tool compound: The discovery of VU0467154 and unexpected DMPK profiles of close analogs
  由: Wood, Michael R., et al.
  出版: (2016)
• Optimization of M(4) positive allosteric modulators (PAMs): The discovery of VU0476406, a non-human primate in vivo tool compound for translational pharmacology
  由: Melancon, Bruce J., et al.
  出版: (2017)
• Discovery and SAR of a novel series of potent, CNS penetrant M(4) PAMs based on a non-enolizable ketone core: Challenges in disposition
  由: Wood, Michael R., et al.
  出版: (2016)