Development of a more highly selective M(1) antagonist from the continued optimization of the MLPCN Probe ML012

This Letter describes the continued optimization of an MLPCN probe molecule (ML012) through an iterative parallel synthesis approach. After exploring extensive modifications throughout the parent structure, we arrived at a more highly M(1)-selective antagonist, compound 13l (VU0415248). Muscarinic s...

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Detalhes bibliográficos
Main Authors: Melancon, Bruce J., Lamers, Alexander P., Bridges, Thomas M., Sulikowski, Gary A., Utley, Thomas J., Sheffler, Douglas J., Noetzel, Meredith J., Morrison, Ryan D., Daniels, J. Scott, Niswender, Colleen M., Jones, Carrie K., Conn, P. Jeffrey, Lindsley, Craig W., Wood, Michael R.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3434972/
https://ncbi.nlm.nih.gov/pubmed/22197142
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2011.11.110
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