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Development of a more highly selective M(1) antagonist from the continued optimization of the MLPCN Probe ML012
This Letter describes the continued optimization of an MLPCN probe molecule (ML012) through an iterative parallel synthesis approach. After exploring extensive modifications throughout the parent structure, we arrived at a more highly M(1)-selective antagonist, compound 13l (VU0415248). Muscarinic s...
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| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2011
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3434972/ https://ncbi.nlm.nih.gov/pubmed/22197142 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2011.11.110 |
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