Lataa...

Development of a more highly selective M(1) antagonist from the continued optimization of the MLPCN Probe ML012

This Letter describes the continued optimization of an MLPCN probe molecule (ML012) through an iterative parallel synthesis approach. After exploring extensive modifications throughout the parent structure, we arrived at a more highly M(1)-selective antagonist, compound 13l (VU0415248). Muscarinic s...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Päätekijät: Melancon, Bruce J., Lamers, Alexander P., Bridges, Thomas M., Sulikowski, Gary A., Utley, Thomas J., Sheffler, Douglas J., Noetzel, Meredith J., Morrison, Ryan D., Daniels, J. Scott, Niswender, Colleen M., Jones, Carrie K., Conn, P. Jeffrey, Lindsley, Craig W., Wood, Michael R.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2011
Aiheet:
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC3434972/
https://ncbi.nlm.nih.gov/pubmed/22197142
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2011.11.110
Tagit: Lisää tagi
Ei tageja, Lisää ensimmäinen tagi!