Identification of Positive Allosteric Modulators VU0155094 (ML397) and VU0422288 (ML396) Reveals New Insights into the Biology of Metabotropic Glutamate Receptor 7

[Image: see text] Metabotropic glutamate receptor 7 (mGlu(7)) is a member of the group III mGlu receptors (mGlus), encompassed by mGlu(4), mGlu(6), mGlu(7), and mGlu(8). mGlu(7) is highly expressed in the presynaptic active zones of both excitatory and inhibitory synapses, and activation of the rece...

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Publicado no:ACS Chem Neurosci
Main Authors: Jalan-Sakrikar, Nidhi, Field, Julie R., Klar, Rebecca, Mattmann, Margrith E., Gregory, Karen J., Zamorano, Rocio, Engers, Darren W., Bollinger, Sean R., Weaver, C. David, Days, Emily L., Lewis, L. Michelle, Utley, Thomas J., Hurtado, Miguel, Rigault, Delphine, Acher, Francine, Walker, Adam G., Melancon, Bruce J., Wood, Michael R., Lindsley, Craig W., Conn, P. Jeffrey, Xiang, Zixiu, Hopkins, Corey R., Niswender, Colleen M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2014
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4306484/
https://ncbi.nlm.nih.gov/pubmed/25225882
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/cn500153z
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