ML297 (VU0456810), the First Potent and Selective Activator of the GIRK Potassium Channel, Displays Antiepileptic Properties in Mice

[Image: see text] The G-protein activated, inward-rectifying potassium (K(+)) channels, “GIRKs”, are a family of ion channels (K(ir)3.1-K(ir)3.4) that has been the focus of intense research interest for nearly two decades. GIRKs are comprised of various homo- and heterotetrameric combinations of fou...

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Detalhes bibliográficos
Main Authors: Kaufmann, Kristian, Romaine, Ian, Days, Emily, Pascual, Conrado, Malik, Adam, Yang, Liya, Zou, Bende, Du, Yu, Sliwoski, Greg, Morrison, Ryan D., Denton, Jerod, Niswender, Colleen M., Daniels, J. Scott, Sulikowski, Gary A., Xie, Xinmin (Simon), Lindsley, Craig W., Weaver, C. David
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2013
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3778424/
https://ncbi.nlm.nih.gov/pubmed/23730969
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/cn400062a
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