Mechanisms underlying the activation of G-protein–gated inwardly rectifying K(+) (GIRK) channels by the novel anxiolytic drug, ML297

ML297 was recently identified as a potent and selective small molecule agonist of G-protein–gated inwardly rectifying K(+) (GIRK/Kir3) channels. Here, we show ML297 selectively activates recombinant neuronal GIRK channels containing the GIRK1 subunit in a manner that requires phosphatidylinositol-4,...

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Detalhes bibliográficos
Main Authors: Wydeven, Nicole, Marron Fernandez de Velasco, Ezequiel, Du, Yu, Benneyworth, Michael A., Hearing, Matthew C., Fischer, Rachel A., Thomas, Mark John, Weaver, C. David, Wickman, Kevin
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2014
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4115558/
https://ncbi.nlm.nih.gov/pubmed/25002517
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1405190111
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