VU0810464, a non‐urea G protein‐gated inwardly rectifying K(+) (K(ir)3/GIRK) channel activator, exhibits enhanced selectivity for neuronal K(ir)3 channels and reduces stress‐induced hyperthermia in mice

BACKGROUND AND PURPOSE: G protein‐gated inwardly rectifying K(+) (K(ir)3) channels moderate the activity of excitable cells and have been implicated in neurological disorders and cardiac arrhythmias. Most neuronal K(ir)3 channels consist of K(ir)3.1 and K(ir)3.2 subtypes, while cardiac K(ir)3 channe...

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Detaylı Bibliyografya
Yayımlandı:Br J Pharmacol
Asıl Yazarlar: Vo, Baovi N., Abney, Kristopher K., Anderson, Allison, Marron Fernandez de Velasco, Ezequiel, Benneyworth, Michael A., Daniels, John Scott, Morrison, Ryan D., Hopkins, Corey R., Weaver, Charles David, Wickman, Kevin
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: John Wiley and Sons Inc. 2019
Konular:
Research Papers
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC6555862/
https://ncbi.nlm.nih.gov/pubmed/30924523
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.14671
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