VU0810464, a non‐urea G protein‐gated inwardly rectifying K(+) (K(ir)3/GIRK) channel activator, exhibits enhanced selectivity for neuronal K(ir)3 channels and reduces stress‐induced hyperthermia in mice

BACKGROUND AND PURPOSE: G protein‐gated inwardly rectifying K(+) (K(ir)3) channels moderate the activity of excitable cells and have been implicated in neurological disorders and cardiac arrhythmias. Most neuronal K(ir)3 channels consist of K(ir)3.1 and K(ir)3.2 subtypes, while cardiac K(ir)3 channe...

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Detalhes bibliográficos
Publicado no:Br J Pharmacol
Main Authors: Vo, Baovi N., Abney, Kristopher K., Anderson, Allison, Marron Fernandez de Velasco, Ezequiel, Benneyworth, Michael A., Daniels, John Scott, Morrison, Ryan D., Hopkins, Corey R., Weaver, Charles David, Wickman, Kevin
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2019
Assuntos:
Research Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6555862/
https://ncbi.nlm.nih.gov/pubmed/30924523
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.14671
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