VU0810464, a non‐urea G protein‐gated inwardly rectifying K(+) (K(ir)3/GIRK) channel activator, exhibits enhanced selectivity for neuronal K(ir)3 channels and reduces stress‐induced hyperthermia in mice

BACKGROUND AND PURPOSE: G protein‐gated inwardly rectifying K(+) (K(ir)3) channels moderate the activity of excitable cells and have been implicated in neurological disorders and cardiac arrhythmias. Most neuronal K(ir)3 channels consist of K(ir)3.1 and K(ir)3.2 subtypes, while cardiac K(ir)3 channe...

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Bibliografiske detaljer
Udgivet i:Br J Pharmacol
Main Authors: Vo, Baovi N., Abney, Kristopher K., Anderson, Allison, Marron Fernandez de Velasco, Ezequiel, Benneyworth, Michael A., Daniels, John Scott, Morrison, Ryan D., Hopkins, Corey R., Weaver, Charles David, Wickman, Kevin
Format: Artigo
Sprog:Inglês
Udgivet: John Wiley and Sons Inc. 2019
Fag:
Research Papers
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6555862/
https://ncbi.nlm.nih.gov/pubmed/30924523
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.14671
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