Synthesis and biological characterization of a series of novel diaryl amide M(1) antagonists

Utilizing a combination of high-throughput and multi-step synthesis, SAR in a novel series of M(1) acetylcholine receptor antagonists was rapidly established. The efforts led to the discovery the highly potent M(1) antagonists 6 (VU0431263), and 8f (VU0433670). Functional Schild analysis and radioli...

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Detalhes bibliográficos
Main Authors: Poslusney, Michael S., Sevel, Christian, Utley, Thomas J., Bridges, Thomas M., Morrison, Ryan D., Kett, Nathan R., Sheffler, Douglas J., Niswender, Colleen M., Daniels, J. S., Conn, P. J., Lindsley, Craig W., Wood, Michael R.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3897205/
https://ncbi.nlm.nih.gov/pubmed/23062550
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2012.09.011
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