Cryo-neutron crystallographic data collection and preliminary refinement of left-handed Z-DNA d(CGCGCG)

Por Harp, Joel M., Coates, Leighton, Sullivan, Brendan, Egli, Martin
Publicado no Acta Crystallogr F Struct Biol Commun (2018)

Structure of the heterodimeric ecdysone receptor DNA-binding complex

Por Devarakonda, Srikripa, Harp, Joel M., Kim, Youngchang, Ożyhar, Andrzej, Rastinejad, Fraydoon
Publicado em 2003

Expedient placement of two fluorescent dyes for investigating dynamic DNA protein interactions in real time

Por Leuba, Sanford H., Anand, Syam P., Harp, Joel M., Khan, Saleem A.
Publicado em 2008

Roles of Residues Arg-61 and Gln-38 of Human DNA Polymerase η in Bypass of Deoxyguanosine and 7,8-Dihydro-8-oxo-2′-deoxyguanosine

Por Su, Yan, Patra, Amritraj, Harp, Joel M., Egli, Martin, Guengerich, F. Peter
Publicado no J Biol Chem (2015)

Computational design of an endo-1,4-β-xylanase ligand binding site

Por Morin, Andrew, Kaufmann, Kristian W., Fortenberry, Carie, Harp, Joel M., Mizoue, Laura S., Meiler, Jens
Publicado em 2011

Analysis of the Structure and Function of YfcG from Escherichia coli Reveals an Efficient and Unique Disulfide Bond Reductase,

Por Wadington, Megan C., Ladner, Jane E., Stourman, Nina V., Harp, Joel M., Armstrong, Richard N.
Publicado em 2009

Total Synthesis of Stemaphylline N-oxide and Related C9a-Epimeric Analogs

Por Schulte, Michael L., Turlington, Mark L., Phatak, Sharangdhar S., Harp, Joel M., Stauffer, Shaun R., Lindsley, Craig W.
Publicado em 2013

Structure and Function of YghU, A Nu-class Glutathione Transferase Related to YfcG from Escherichia coli,

Por Stourman, Nina V., Branch, Megan C., Schaab, Matthew R., Harp, Joel M., Ladner, Jane E., Armstrong, Richard N.
Publicado em 2011

Molecular Basis for Cyclooxygenase Inhibition by the Non-steroidal Anti-inflammatory Drug Naproxen

Por Duggan, Kelsey C., Walters, Matthew J., Musee, Joel, Harp, Joel M., Kiefer, James R., Oates, John A., Marnett, Lawrence J.
Publicado em 2010

Evaluation of TSPO PET Ligands [(18)F]VUIIS1009A and [(18)F]VUIIS1009B: Tracers for Cancer Imaging

Por Tang, Dewei, Li, Jun, Buck, Jason R., Tantawy, Mohamed Noor, Xia, Yan, Harp, Joel M., Nickels, Michael L., Meiler, Jens, Manning, H. Charles
Publicado no Mol Imaging Biol (2017)

Synthesis and Structure-Activity Relationships of 5,6,7-substituted Pyrazolopyrimidines: Discovery of a novel TSPO PET Ligand for Cancer Imaging

Por Tang, Dewei, McKinley, Eliot T., Hight, Matthew R., Uddin, Md. Imam, Harp, Joel M., Fu, Allie, Nickels, Michael L., Buck, Jason R., Manning, H. Charles
Publicado em 2013

Crystal Structures of Trypanosoma brucei Sterol 14α-Demethylase and Implications for Selective Treatment of Human Infections

Por Lepesheva, Galina I., Park, Hee-Won, Hargrove, Tatiana Y., Vanhollebeke, Benoit, Wawrzak, Zdzislaw, Harp, Joel M., Sundaramoorthy, Munirathinam, Nes, W. David, Pays, Etienne, Chaudhuri, Minu, Villalta, Fernando, Waterman, Michael R.
Publicado em 2010

Structural basis for the synergy of 4′- and 2′-modifications on siRNA nuclease resistance, thermal stability and RNAi activity

Por Harp, Joel M, Guenther, Dale C, Bisbe, Anna, Perkins, Lydia, Matsuda, Shigeo, Bommineni, Gopal R, Zlatev, Ivan, Foster, Donald J, Taneja, Nate, Charisse, Klaus, Maier, Martin A, Rajeev, Kallanthottathil G, Manoharan, Muthiah, Egli, Martin
Publicado no Nucleic Acids Res (2018)

Discovery of the first M(5)-selective and CNS penetrant negative allosteric modulator (NAM) of a muscarinic acetylcholine receptor: (S)-9b-(4-chlorophenyl)-1-(3,4-difluorobenzoyl)-...

Por Gentry, Patrick R., Kokubo, Masaya, Bridges, Thomas M., Kett, Nathan R., Harp, Joel M., Cho, Hyekyung P., Smith, Emery, Chase, Peter, Hodder, Peter S., Niswender, Colleen M., Daniels, J. Scott, Conn, P. Jeffrey, Wood, Michael R., Lindsley, Craig W.
Publicado em 2013

Discovery of VU6005649, a CNS Penetrant mGlu(7/8) Receptor PAM Derived from a Series of Pyrazolo[1,5-a]pyrimidines

Por Abe, Masahito, Seto, Mabel, Gogliotti, Rocco G., Loch, Matthew T., Bollinger, Katrina A., Chang, Sichen, Engelberg, Eileen M., Luscombe, Vincent B., Harp, Joel M., Bubser, Michael, Engers, Darren W., Jones, Carrie K., Rodriguez, Alice L., Blobaum, Anna L., Conn, P. Jeffrey, Niswender, Colleen M., Lindsley, Craig W.
Publicado no ACS Med Chem Lett (2017)

A Novel M(1) PAM VU0486846 Exerts Efficacy in Cognition Models without Displaying Agonist Activity or Cholinergic Toxicity

Por Rook, Jerri M., Bertron, Jeanette L., Cho, Hyekyung P., Garcia-Barrantes, Pedro M., Moran, Sean P., Maksymetz, James T., Nance, Kellie D., Dickerson, Jonathan W., Remke, Daniel H., Chang, Sichen, Harp, Joel M., Blobaum, Anna L., Niswender, Colleen M., Jones, Carrie K., Stauffer, Shaun R., Conn, P. Jeffrey, Lindsley, Craig W.
Publicado no ACS Chem Neurosci (2018)