A requirement for an active proton delivery network supports a compound I-mediated C–C bond cleavage in CYP51 catalysis

por Hargrove, Tatiana Y., Wawrzak, Zdzislaw, Guengerich, F. Peter, Lepesheva, Galina I.
Publicado no J Biol Chem (2020)

Structure and DNA binding of alkylation response protein AidB

por Bowles, Timothy, Metz, Audrey H., O'Quin, Jami, Wawrzak, Zdzislaw, Eichman, Brandt F.
Publicado em 2008

Validation of Human Sterol 14α-Demethylase (CYP51) Druggability: Structure-Guided Design, Synthesis, and Evaluation of Stoichiometric, Functionally Irreversible Inhibitors

por Friggeri, Laura, Hargrove, Tatiana Y., Wawrzak, Zdzislaw, Guengerich, F. Peter, Lepesheva, Galina I.
Publicado no J Med Chem (2019)

Structure-Functional Characterization of Cytochrome P450 Sterol 14α-Demethylase (CYP51B) from Aspergillus fumigatus and Molecular Basis for the Development of Antifungal Drugs

por Hargrove, Tatiana Y., Wawrzak, Zdzislaw, Lamb, David C., Guengerich, F. Peter, Lepesheva, Galina I.
Publicado no J Biol Chem (2015)

Structure of the TDP-epi-vancosaminyltransferase GtfA from the chloroeremomycin biosynthetic pathway

por Mulichak, Anne M., Losey, Heather C., Lu, Wei, Wawrzak, Zdzislaw, Walsh, Christopher T., Garavito, R. Michael
Publicado em 2003

2′-Fluoroarabino- and Arabinonucleic Acid Show Different Conformations, Resulting in Deviating RNA Affinities and Processing of Their Heteroduplexes with RNA by RNase H

por Li, Feng, Sarkhel, Sanjay, Wilds, Christopher J., Wawrzak, Zdzislaw, Prakash, Thazha P., Manoharan, Muthiah, Egli, Martin
Publicado em 2006

Substrate Preferences and Catalytic Parameters Determined by Structural Characteristics of Sterol 14α-Demethylase (CYP51) from Leishmania infantum

por Hargrove, Tatiana Y., Wawrzak, Zdzislaw, Liu, Jialin, Nes, W. David, Waterman, Michael R., Lepesheva, Galina I.
Publicado em 2011

Structural complex of sterol 14α-demethylase (CYP51) with 14α-methylenecyclopropyl-Δ7-24, 25-dihydrolanosterol

por Hargrove, Tatiana Y., Wawrzak, Zdzislaw, Liu, Jialin, Waterman, Michael R., Nes, W. David, Lepesheva, Galina I.
Publicado em 2012

Substrate Recognition by a Colistin Resistance Enzyme from Moraxella catarrhalis

por Stogios, Peter J., Cox, Georgina, Zubyk, Haley L., Evdokimova, Elena, Wawrzak, Zdzislaw, Wright, Gerard D., Savchenko, Alexei
Publicado no ACS Chem Biol (2018)

Crystal Structure of a Luteoviral RNA Pseudoknot and Model for a Minimal Ribosomal Frameshifting Motif ,

por Pallan, Pradeep S., Marshall, William S., Harp, Joel, Jewett, Frederic C., Wawrzak, Zdzislaw, Brown, Bernard A., Rich, Alexander, Egli, Martin
Publicado em 2005

Crystal structure of nonphosphorylated receiver domain of the stress response regulator RcsB from Escherichia coli

por Filippova, Ekaterina V., Wawrzak, Zdzislaw, Ruan, Jiapeng, Pshenychnyi, Sergii, Schultz, Richard M., Wolfe, Alan J., Anderson, Wayne F.
Publicado no Protein Sci (2016)

Novel carbohydrate binding modules in the surface anchored α-amylase of Eubacterium rectale provide a molecular rationale for the range of starches used by this organism in the hum...

por Cockburn, Darrell W., Suh, Carolyn, Medina, Krizia Perez, Duvall, Rebecca M., Wawrzak, Zdzislaw, Henrissat, Bernard, Koropatkin, Nicole M.
Publicado no Mol Microbiol (2017)

Cytochrome c nitrite reductase from the bacterium Geobacter lovleyi represents a new NrfA subclass

por Campeciño, Julius, Lagishetty, Satyanarayana, Wawrzak, Zdzislaw, Sosa Alfaro, Victor, Lehnert, Nicolai, Reguera, Gemma, Hu, Jian, Hegg, Eric L.
Publicado no J Biol Chem (2020)

Supramolecular Allosteric Cofacial Porphyrin Complexes

por Oliveri, Christopher G., Gianneschi, Nathan C., Nguyen, SonBinh T., Mirkin, Chad A., Stern, Charlotte L., Wawrzak, Zdzislaw, Pink, Maren
Publicado em 2006

Structural Insights into Inhibition of Sterol 14α-Demethylase in the Human Pathogen Trypanosoma cruzi

por Lepesheva, Galina I., Hargrove, Tatiana Y., Anderson, Spencer, Kleshchenko, Yuliya, Furtak, Vyacheslav, Wawrzak, Zdzislaw, Villalta, Fernando, Waterman, Michael R.
Publicado em 2010

Crystal structures of the transpeptidase domain of the Mycobacterium tuberculosis penicillin‐binding protein PonA1 reveal potential mechanisms of antibiotic resistance

por Filippova, Ekaterina V., Kieser, Karen J., Luan, Chi‐Hao, Wawrzak, Zdzislaw, Kiryukhina, Olga, Rubin, Eric J., Anderson, Wayne F.
Publicado no FEBS J (2016)

Recognition of O(6)-benzyl-2′-deoxyguanosine by a perimidinone-derived synthetic nucleoside: a DNA interstrand stacking interaction

por Kowal, Ewa A., Lad, Rahul R., Pallan, Pradeep S., Dhummakupt, Elizabeth, Wawrzak, Zdzislaw, Egli, Martin, Sturla, Shana J., Stone, Michael P.
Publicado em 2013

Detection of alkali metal ions in DNA crystals using state-of-the-art X-ray diffraction experiments

por Tereshko, Valentina, Wilds, Christopher J., Minasov, George, Prakash, Thaza P., Maier, Martin A., Howard, Andrew, Wawrzak, Zdzislaw, Manoharan, Muthiah, Egli, Martin
Publicado em 2001

Basis of Miscoding of the DNA Adduct N(2),3-Ethenoguanine by Human Y-family DNA Polymerases

por Zhao, Linlin, Pence, Matthew G., Christov, Plamen P., Wawrzak, Zdzislaw, Choi, Jeong-Yun, Rizzo, Carmelo J., Egli, Martin, Guengerich, F. Peter
Publicado em 2012

Crystal Structure of the New Investigational Drug Candidate VT-1598 in Complex with Aspergillus fumigatus Sterol 14α-Demethylase Provides Insights into Its Broad-Spectrum Antifunga...

por Hargrove, Tatiana Y., Garvey, Edward P., Hoekstra, William J., Yates, Christopher M., Wawrzak, Zdzislaw, Rachakonda, Girish, Villalta, Fernando, Lepesheva, Galina I.
Publicado no Antimicrob Agents Chemother (2017)