Structural Insights into Inhibition of Sterol 14α-Demethylase in the Human Pathogen Trypanosoma cruzi

Trypanosoma cruzi causes Chagas disease (American trypanosomiasis), which threatens the lives of millions of people and remains incurable in its chronic stage. The antifungal drug posaconazole that blocks sterol biosynthesis in the parasite is the only compound entering clinical trials for the chron...

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Detalhes bibliográficos
Main Authors: Lepesheva, Galina I., Hargrove, Tatiana Y., Anderson, Spencer, Kleshchenko, Yuliya, Furtak, Vyacheslav, Wawrzak, Zdzislaw, Villalta, Fernando, Waterman, Michael R.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2010
Assuntos:
Protein Structure and Folding
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2919122/
https://ncbi.nlm.nih.gov/pubmed/20530488
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.133215
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