Structural Insights into Inhibition of Sterol 14α-Demethylase in the Human Pathogen Trypanosoma cruzi

Trypanosoma cruzi causes Chagas disease (American trypanosomiasis), which threatens the lives of millions of people and remains incurable in its chronic stage. The antifungal drug posaconazole that blocks sterol biosynthesis in the parasite is the only compound entering clinical trials for the chron...

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Autores principales: Lepesheva, Galina I., Hargrove, Tatiana Y., Anderson, Spencer, Kleshchenko, Yuliya, Furtak, Vyacheslav, Wawrzak, Zdzislaw, Villalta, Fernando, Waterman, Michael R.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2010
Materias:
Protein Structure and Folding
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2919122/
https://ncbi.nlm.nih.gov/pubmed/20530488
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.133215
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