Indomethacin Amides as a Novel Molecular Scaffold for Targeting Trypanosoma cruzi Sterol 14α-Demethylase

Trypanosoma cruzi (TC) causes Chagas disease, which in its chronic stage remains incurable. We have shown recently that specific inhibition of TC sterol 14α-demethylase (TCCYP51) with imidazole derivatives is effective in killing both extracellular and intracellular human stages of TC. An alternativ...

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Detalhes bibliográficos
Main Authors: Konkle, Mary E., Hargrove, Tatiana Y., Kleshchenko, Yuliya Y., von Kries, Jens P., Ridenour, Whitney, Uddin, Md. Jashim, Caprioli, Richard M., Marnett, Lawrence J., Nes, W. David, Villalta, Fernando, Waterman, Michael R., Lepesheva, Galina I.
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2744100/
https://ncbi.nlm.nih.gov/pubmed/19354253
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm801643b
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