Sterol 14α-demethylase as a potential target for antitrypanosomal therapy: enzyme inhibition and parasite cell growth

Sterol 14α-demethylases (CYP51) serve as primary targets for antifungal drugs and specific inhibition of CYP51s in protozoan parasites Trypanosoma brucei (TB) and Trypanosoma cruzi (TC) might provide an effective treatment strategy for human trypanosomiases. Primary inhibitor selection is based init...

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Hoofdauteurs: Lepesheva, Galina I., Ott, Robert D., Hargrove, Tatiana Y., Kleshchenko, Yuliya Y., Schuster, Inge, Nes, W. David, Hill, George C., Villalta, Fernando, Waterman, Michael R.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2007
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2324070/
https://ncbi.nlm.nih.gov/pubmed/18022567
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2007.10.011
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