Sterol 14α-demethylase as a potential target for antitrypanosomal therapy: enzyme inhibition and parasite cell growth

Sterol 14α-demethylases (CYP51) serve as primary targets for antifungal drugs and specific inhibition of CYP51s in protozoan parasites Trypanosoma brucei (TB) and Trypanosoma cruzi (TC) might provide an effective treatment strategy for human trypanosomiases. Primary inhibitor selection is based init...

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Hlavní autoři: Lepesheva, Galina I., Ott, Robert D., Hargrove, Tatiana Y., Kleshchenko, Yuliya Y., Schuster, Inge, Nes, W. David, Hill, George C., Villalta, Fernando, Waterman, Michael R.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2007
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2324070/
https://ncbi.nlm.nih.gov/pubmed/18022567
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2007.10.011
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