Recognition of O(6)-benzyl-2′-deoxyguanosine by a perimidinone-derived synthetic nucleoside: a DNA interstrand stacking interaction

The 2′-deoxynucleoside containing the synthetic base 1-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)-tetrahydrofuran-2-yl)-1H-perimidin-2(3H)-one] (dPer) recognizes in DNA the O(6)-benzyl-2′-deoxyguanosine nucleoside (O(6)-Bn-dG), formed by exposure to N-benzylmethylnitrosamine. Herein, we show how dPer d...

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Detalhes bibliográficos
Main Authors: Kowal, Ewa A., Lad, Rahul R., Pallan, Pradeep S., Dhummakupt, Elizabeth, Wawrzak, Zdzislaw, Egli, Martin, Sturla, Shana J., Stone, Michael P.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2013
Assuntos:
Synthetic Biology and Chemistry
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3753623/
https://ncbi.nlm.nih.gov/pubmed/23748954
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkt488
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