O(6)-2′-Deoxyguanosine-butylene-O(6)-2′-deoxyguanosine DNA Interstrand Cross-Links Are Replication-Blocking and Mutagenic DNA Lesions

DNA interstrand cross-links (ICLs) are cytotoxic DNA lesions derived from reactions of DNA with a number of anti-cancer reagents as well as endogenous bifunctional electrophiles. Deciphering the DNA repair mechanisms of ICLs is important for understanding the toxicity of DNA cross-linking agents and...

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Detalhes bibliográficos
Publicado no:Chem Res Toxicol
Main Authors: Xu, Wenyan, Kool, Daniel, O’Flaherty, Derek K., Keating, Ashley M., Sacre, Lauralicia, Egli, Martin, Noronha, Anne, Wilds, Christopher J., Zhao, Linlin
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5665164/
https://ncbi.nlm.nih.gov/pubmed/27768841
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.chemrestox.6b00278
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