Repair of O(6)-G-alkyl-O(6)-G interstrand cross-links by human O(6)-alkylguanine-DNA alkyltransferase

O(6)-Alkylguanine-DNA alkyltransferase (AGT) plays an important role protecting cells from alkylating agents. This reduces carcinogenesis and mutagenesis initiated by such agents but AGT also provides a major resistance mechanism to some chemotherapeutic drugs. In order to improve understanding of t...

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Huvudupphovsmän: Fang, Qingming, Noronha, Anne M., Murphy, Sebastian P., Wilds, Christopher J., Tubbs, Julie L., Tainer, John A., Chowdhury, Goutam, Guengerich, F. Peter, Pegg, Anthony E.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2008
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2632579/
https://ncbi.nlm.nih.gov/pubmed/18803403
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi8008664
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