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Repair of O(4)-Alkylthymine by O(6)-Alkylguanine-DNA Alkyltransferases

O(6)-Alkylguanine-DNA alkyltransferase (AGT) plays a major role in repair of the cytotoxic and mutagenic lesion O(6)-methylguanine (m(6)G) in DNA. Unlike the Escherichia coli alkyltransferase Ogt that also repairs O(4)-methylthymine (m(4)T) efficiently, the human AGT (hAGT) acts poorly on m(4)T. Her...

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Detalhes bibliográficos
Main Authors: Fang, Qingming, Kanugula, Sreenivas, Tubbs, Julie L., Tainer, John A., Pegg, Anthony E.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2832970/
https://ncbi.nlm.nih.gov/pubmed/20026607
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.045518
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