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Repair of O(4)-Alkylthymine by O(6)-Alkylguanine-DNA Alkyltransferases
O(6)-Alkylguanine-DNA alkyltransferase (AGT) plays a major role in repair of the cytotoxic and mutagenic lesion O(6)-methylguanine (m(6)G) in DNA. Unlike the Escherichia coli alkyltransferase Ogt that also repairs O(4)-methylthymine (m(4)T) efficiently, the human AGT (hAGT) acts poorly on m(4)T. Her...
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| Главные авторы: | , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
American Society for Biochemistry and Molecular Biology
2010
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2832970/ https://ncbi.nlm.nih.gov/pubmed/20026607 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.045518 |
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