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Synthesis and Characterization of Oligonucleotides Containing an O(6)-2′-Deoxyguanosine-Alkyl-O(6)-2′-Deoxyguanosine Interstrand Cross-Link in a 5′-GNC Motif and Repair by Human O(6)-Alkylguanine-DNA Alkyltransferase
O(6)-2′-Deoxyguanosine-alkyl-O(6)-2′-deoxyguanosine interstrand DNA cross-links (ICL) with a four and seven methylene linkage in a 5′-GNC- motif have been synthesized and their repair by human O6-alkylguanine-DNA alkyltransferase (hAGT) investigated. Duplexes containing 11 base-pairs with the ICL in...
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| Asıl Yazarlar: | , , , , , |
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| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
2010
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| Konular: | |
| Online Erişim: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3021135/ https://ncbi.nlm.nih.gov/pubmed/20714665 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c0ob00093k |
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