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Inactivation of O(6)-alkylguanine-DNA alkyltransferase by folate esters of O(6)-benzyl-2′-deoxyguanosine and of O(6)-[4-(hydroxymethyl)benzyl]guanine
O(6)-Alkylguanine-DNA alkyltransferase (alkyltransferase) provides an important source of resistance to some cancer chemotherapeutic alkylating agents. Folate ester derivatives of O(6)-benzyl-2′-deoxyguanosine and of O(6)-[4-(hydroxymethyl)benzyl]guanine were synthesized and tested for their ability...
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| Hauptverfasser: | , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2007
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2597536/ https://ncbi.nlm.nih.gov/pubmed/17880193 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm0705859 |
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