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Differential inactivation of polymorphic variants of human O(6)-alkylguanine-DNA alkyltransferase
The human DNA repair protein O(6)-alkylguanine-DNA alkyltransferase (hAGT) is an important source of resistance to some therapeutic alkylating agents and attempts to circumvent this resistance by the use of hAGT inhibitors have reached clinical trials. Several human polymorphisms in the MGMT gene th...
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| Main Authors: | , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2007
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2275801/ https://ncbi.nlm.nih.gov/pubmed/17996846 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bcp.2007.09.022 |
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