Inactivation of O(6)-alkylguanine-DNA alkyltransferase by folate esters of O(6)-benzyl-2′-deoxyguanosine and of O(6)-[4-(hydroxymethyl)benzyl]guanine

O(6)-Alkylguanine-DNA alkyltransferase (alkyltransferase) provides an important source of resistance to some cancer chemotherapeutic alkylating agents. Folate ester derivatives of O(6)-benzyl-2′-deoxyguanosine and of O(6)-[4-(hydroxymethyl)benzyl]guanine were synthesized and tested for their ability...

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Bibliografiska uppgifter
Huvudupphovsmän: Javanmard, Sahar, Loktionova, Natalia A., Fang, Qingming, Pauly, Gary T., Pegg, Anthony E., Moschel, Robert C.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2007
Ämnen:
Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2597536/
https://ncbi.nlm.nih.gov/pubmed/17880193
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm0705859
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