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Active-site alkylation destabilizes human O(6)-alkylguanine DNA alkyltransferase
O(6)-alkylguanine-DNA alkyltransferase (AGT) repairs pro-mutagenic O(6)-alkylguanine and O(4)-alkylthymine lesions in DNA. The alkylated form of the protein is not reactivated; instead, it is rapidly ubiquitinated and degraded. Here, we show that alkylation destabilizes the native fold of the protei...
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| Auteurs principaux: | , , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
Cold Spring Harbor Laboratory Press
2004
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2286524/ https://ncbi.nlm.nih.gov/pubmed/14691244 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1110/ps.03319404 |
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