Active-site alkylation destabilizes human O(6)-alkylguanine DNA alkyltransferase

O(6)-alkylguanine-DNA alkyltransferase (AGT) repairs pro-mutagenic O(6)-alkylguanine and O(4)-alkylthymine lesions in DNA. The alkylated form of the protein is not reactivated; instead, it is rapidly ubiquitinated and degraded. Here, we show that alkylation destabilizes the native fold of the protei...

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Autores principales: Rasimas, Joseph J., Dalessio, Paula A., Ropson, Ira J., Pegg, Anthony E., Fried, Michael G.
Formato: Artigo
Lenguaje:Inglês
Publicado: Cold Spring Harbor Laboratory Press 2004
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For the Record
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2286524/
https://ncbi.nlm.nih.gov/pubmed/14691244
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1110/ps.03319404
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