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Active-site alkylation destabilizes human O(6)-alkylguanine DNA alkyltransferase
O(6)-alkylguanine-DNA alkyltransferase (AGT) repairs pro-mutagenic O(6)-alkylguanine and O(4)-alkylthymine lesions in DNA. The alkylated form of the protein is not reactivated; instead, it is rapidly ubiquitinated and degraded. Here, we show that alkylation destabilizes the native fold of the protei...
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| Autori principali: | , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Cold Spring Harbor Laboratory Press
2004
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2286524/ https://ncbi.nlm.nih.gov/pubmed/14691244 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1110/ps.03319404 |
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