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TOPOLOGIES OF COMPLEXES CONTAINING O(6)-ALKYLGUANINE-DNA ALKYLTRANSFERASE AND DNA
The mutagenic and cytotoxic effects of many alkylating agents are reduced by O(6)-alkylguanine-DNA alkyltransferase (AGT). In humans this protein protects the integrity of the genome, but also contributes to the resistance of tumors to DNA-alkylating chemotherapeutic agents. Here we describe and tes...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2736636/ https://ncbi.nlm.nih.gov/pubmed/19358853 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2009.03.067 |
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