TOPOLOGIES OF COMPLEXES CONTAINING O(6)-ALKYLGUANINE-DNA ALKYLTRANSFERASE AND DNA

The mutagenic and cytotoxic effects of many alkylating agents are reduced by O(6)-alkylguanine-DNA alkyltransferase (AGT). In humans this protein protects the integrity of the genome, but also contributes to the resistance of tumors to DNA-alkylating chemotherapeutic agents. Here we describe and tes...

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Main Authors: Adams, Claire A., Melikishvili, Manana, Rodgers, David W., Rasimas, Joseph J., Pegg, Anthony E., Fried, Michael G.
Format: Artigo
Jezik:Inglês
Izdano: 2009
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2736636/
https://ncbi.nlm.nih.gov/pubmed/19358853
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2009.03.067
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