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Cooperative cluster formation, DNA bending and base-flipping by O(6)-alkylguanine-DNA alkyltransferase
O(6)-Alkylguanine-DNA alkyltransferase (AGT) repairs mutagenic O(6)-alkylguanine and O(4)-alkylthymine adducts in DNA, protecting the genome and also contributing to the resistance of tumors to chemotherapeutic alkylating agents. AGT binds DNA cooperatively, and cooperative interactions are likely t...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3458534/ https://ncbi.nlm.nih.gov/pubmed/22730295 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gks574 |
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