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Quaternary interactions and supercoiling modulate the cooperative DNA binding of AGT
Human O(6)-alkylguanine-DNA alkyltransferase (AGT) repairs mutagenic O(6)-alkylguanine and O(4)-alkylthymine adducts in single-stranded and duplex DNAs. The search for these lesions, through a vast excess of competing, unmodified genomic DNA, is a mechanistic challenge that may limit the repair rate...
Tallennettuna:
| Julkaisussa: | Nucleic Acids Res |
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| Päätekijät: | , |
| Aineistotyyppi: | Artigo |
| Kieli: | Inglês |
| Julkaistu: |
Oxford University Press
2017
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| Aiheet: | |
| Linkit: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5737729/ https://ncbi.nlm.nih.gov/pubmed/28575445 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkx223 |
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