6-Carboxyfluorescein And Structurally-Similar Molecules Inhibit DNA Binding And Repair By O(6)-Alkylguanine DNA Alkyltransferase

Human O(6)-alkylguanine-DNA alkyltransferase (AGT) repairs mutagenic O(6)-alkylguanine and O(4)-alkylthymine adducts in single-stranded and duplex DNAs. These activities protect normal cells and tumor cells against drugs that alkylate DNA; drugs that inactivate AGT are under test as chemotherapeutic...

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Bibliografski detalji
Glavni autori: Melikishvili, Manana, Rodgers, David W., Fried, Michael G.
Format: Artigo
Jezik:Inglês
Izdano: 2011
Teme:
Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3217094/
https://ncbi.nlm.nih.gov/pubmed/21982443
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.dnarep.2011.09.007
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