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6-Carboxyfluorescein And Structurally-Similar Molecules Inhibit DNA Binding And Repair By O(6)-Alkylguanine DNA Alkyltransferase
Human O(6)-alkylguanine-DNA alkyltransferase (AGT) repairs mutagenic O(6)-alkylguanine and O(4)-alkylthymine adducts in single-stranded and duplex DNAs. These activities protect normal cells and tumor cells against drugs that alkylate DNA; drugs that inactivate AGT are under test as chemotherapeutic...
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| Hlavní autoři: | , , |
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| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
2011
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3217094/ https://ncbi.nlm.nih.gov/pubmed/21982443 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.dnarep.2011.09.007 |
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