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Synthesis and Characterization of Oligonucleotides Containing an O(6)-2′-Deoxyguanosine-Alkyl-O(6)-2′-Deoxyguanosine Interstrand Cross-Link in a 5′-GNC Motif and Repair by Human O(6)-Alkylguanine-DNA Alkyltransferase

O(6)-2′-Deoxyguanosine-alkyl-O(6)-2′-deoxyguanosine interstrand DNA cross-links (ICL) with a four and seven methylene linkage in a 5′-GNC- motif have been synthesized and their repair by human O6-alkylguanine-DNA alkyltransferase (hAGT) investigated. Duplexes containing 11 base-pairs with the ICL in...

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Main Authors: McManus, Francis P., Fang, Qingming, Booth, Jason D. M., Noronha, Anne M., Pegg, Anthony E., Wilds, Christopher J.
Format: Artigo
Jezik:Inglês
Izdano: 2010
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3021135/
https://ncbi.nlm.nih.gov/pubmed/20714665
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c0ob00093k
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