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Detection and Characterization of Ethylene Dibromide-Derived DNA-Crosslinks Formed with O(6)-Alkylguanine-DNA Alkyltransferase()

The chemical structures of DNA-protein crosslinks (DPCs) are necessary for understanding mechanisms of mutagenesis, but structural analysis of DPCs is limited because the modifications are bulky. Using a combination of LC-tandem MS and chemical modification approaches, we have characterized the stru...

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Hlavní autoři: Chowdhury, Goutam, Cho, Sung-Hee, Pegg, Anthony E., Guengerich, F. Peter
Médium: Artigo
Jazyk:Inglês
Vydáno: 2013
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4048925/
https://ncbi.nlm.nih.gov/pubmed/24130045
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201307580
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