Mutagenic Bypass of an Oxidized Abasic Lesion-Induced DNA Interstrand Cross-Link Analogue by Human Translesion Synthesis DNA Polymerases

5′-(2-Phosphoryl-1,4-dioxobutane) (DOB) is an oxidized abasic site that is produced by several antitumor agents and γ-radiolysis. DOB reacts reversibly with a dA opposite the 3′-adjacent nucleotide to form DNA interstrand cross-links (ICLs), genotoxic DNA lesions that can block DNA replication and t...

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Detalhes bibliográficos
Publicado no:Biochemistry
Main Authors: Xu, Wenyan, Ouellette, Adam, Ghosh, Souradyuti, O’Neill, Tylor C., Greenberg, Marc M., Zhao, Linlin
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4700817/
https://ncbi.nlm.nih.gov/pubmed/26626537
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.5b01027
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