Mutagenic Bypass of an Oxidized Abasic Lesion-Induced DNA Interstrand Cross-Link Analogue by Human Translesion Synthesis DNA Polymerases

5′-(2-Phosphoryl-1,4-dioxobutane) (DOB) is an oxidized abasic site that is produced by several antitumor agents and γ-radiolysis. DOB reacts reversibly with a dA opposite the 3′-adjacent nucleotide to form DNA interstrand cross-links (ICLs), genotoxic DNA lesions that can block DNA replication and t...

Descripció completa

Guardat en:
Dades bibliogràfiques
Publicat a:Biochemistry
Autors principals: Xu, Wenyan, Ouellette, Adam, Ghosh, Souradyuti, O’Neill, Tylor C., Greenberg, Marc M., Zhao, Linlin
Format: Artigo
Idioma:Inglês
Publicat: 2015
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4700817/
https://ncbi.nlm.nih.gov/pubmed/26626537
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.5b01027
Etiquetes: Afegir etiqueta
Sense etiquetes, Sigues el primer a etiquetar aquest registre!

Ítems similars