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Structure-dependent bypass of DNA interstrand crosslinks by translesion synthesis polymerases

DNA interstrand crosslinks (ICLs), inhibit DNA metabolism by covalently linking two strands of DNA and are formed by antitumor agents such as cisplatin and nitrogen mustards. Multiple complex repair pathways of ICLs exist in humans that share translesion synthesis (TLS) past a partially processed IC...

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Hlavní autoři: Ho, The Vinh, Guainazzi, Angelo, Derkunt, Semsi Burak, Enoiu, Milica, Schärer, Orlando D.
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2011
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3177197/
https://ncbi.nlm.nih.gov/pubmed/21666254
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkr448
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