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The structure and duplex context of DNA interstrand crosslinks affects the activity of DNA polymerase η

Several important anti-tumor agents form DNA interstrand crosslinks (ICLs), but their clinical efficiency is counteracted by multiple complex DNA repair pathways. All of these pathways require unhooking of the ICL from one strand of a DNA duplex by nucleases, followed by bypass of the unhooked ICL b...

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Detalles Bibliográficos
Publicado en:Nucleic Acids Res
Main Authors: Roy, Upasana, Mukherjee, Shivam, Sharma, Anjali, Frank, Ekaterina G., Schärer, Orlando D.
Formato: Artigo
Idioma:Inglês
Publicado: Oxford University Press 2016
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5009737/
https://ncbi.nlm.nih.gov/pubmed/27257072
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkw485
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