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The structure and duplex context of DNA interstrand crosslinks affects the activity of DNA polymerase η

Several important anti-tumor agents form DNA interstrand crosslinks (ICLs), but their clinical efficiency is counteracted by multiple complex DNA repair pathways. All of these pathways require unhooking of the ICL from one strand of a DNA duplex by nucleases, followed by bypass of the unhooked ICL b...

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Detaylı Bibliyografya
Yayımlandı:Nucleic Acids Res
Asıl Yazarlar: Roy, Upasana, Mukherjee, Shivam, Sharma, Anjali, Frank, Ekaterina G., Schärer, Orlando D.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Oxford University Press 2016
Konular:
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5009737/
https://ncbi.nlm.nih.gov/pubmed/27257072
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkw485
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