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Involvement of Translesion Synthesis DNA Polymerases in DNA Interstrand Crosslink Repair

DNA interstrand crosslinks (ICLs) covalently join the two strands of a DNA duplex and block essential processes such as DNA replication and transcription. Several important anti-tumor drugs such as cisplatin and nitrogen mustards exert their cytotoxicity by forming ICLs. However, multiple complex pa...

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Publicado en:DNA Repair (Amst)
Autores principales: Roy, Upasana, Schärer, Orlando D.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2016
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5524570/
https://ncbi.nlm.nih.gov/pubmed/27311543
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.dnarep.2016.05.004
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