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Structure-dependent bypass of DNA interstrand crosslinks by translesion synthesis polymerases
DNA interstrand crosslinks (ICLs), inhibit DNA metabolism by covalently linking two strands of DNA and are formed by antitumor agents such as cisplatin and nitrogen mustards. Multiple complex repair pathways of ICLs exist in humans that share translesion synthesis (TLS) past a partially processed IC...
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| Hauptverfasser: | , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Oxford University Press
2011
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3177197/ https://ncbi.nlm.nih.gov/pubmed/21666254 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkr448 |
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