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Generation of DNA Interstrand Crosslinks by Post-Synthetic Reductive Amination
[Image: see text] DNA interstrand crosslinks (ICLs) are the clinically most relevant adducts formed by many anti-tumor agents. To facilitate the study of biological responses triggered by ICLs, we developed a new approach toward the synthesis of mimics of nitrogen mustard ICLs. 7-Deazaguanine residu...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2635425/ https://ncbi.nlm.nih.gov/pubmed/19132933 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ol802719a |
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