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Using synthetic DNA interstrand crosslinks to elucidate repair pathways and identify new therapeutic targets for cancer chemotherapy

Many cancer chemotherapic agents form DNA interstrand crosslinks (ICLs), extremely cytotoxic lesions that form covalent bonds between two opposing DNA strands, blocking DNA replication and transcription. However, cellular responses triggered by ICLs can cause resistance in tumor cells, limiting the...

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Detaylı Bibliyografya
Asıl Yazarlar: Guainazzi, Angelo, Schärer, Orlando D.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2010
Konular:
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3732395/
https://ncbi.nlm.nih.gov/pubmed/20730555
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00018-010-0492-6
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