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Synthesis and Molecular Modeling of a Nitrogen Mustard DNA Interstrand Crosslink

Nitrogen Mustard Reloaded: Over 60 years after nitrogen mustards (NMs) were the first agents used to treat tumors by chemotherapy, we provide a method to generate the main DNA adduct formed by NMs and validate them using molecular dynamics simulations. We are able to provide amounts permitting exten...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Chemistry
Prif Awduron: Guainazzi, Angelo, Campbell, Arthur J., Angelov, Todor, Simmerling, Carlos, Schärer, Orlando D.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2010
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4870935/
https://ncbi.nlm.nih.gov/pubmed/20842675
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/chem.201002041
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