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Synthesis and Molecular Modeling of a Nitrogen Mustard DNA Interstrand Crosslink
Nitrogen Mustard Reloaded: Over 60 years after nitrogen mustards (NMs) were the first agents used to treat tumors by chemotherapy, we provide a method to generate the main DNA adduct formed by NMs and validate them using molecular dynamics simulations. We are able to provide amounts permitting exten...
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| Опубликовано в: : | Chemistry |
|---|---|
| Главные авторы: | , , , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2010
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4870935/ https://ncbi.nlm.nih.gov/pubmed/20842675 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/chem.201002041 |
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