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Nucleotide Excision Repair of Chemically Stabilized Analogues of DNA Interstrand Cross-Links Produced from Oxidized Abasic Sites

[Image: see text] Nucleotide excision repair is a primary pathway in cells for coping with DNA interstrand cross-links (ICLs). Recently, C4′-oxidized (C4-AP) and C5′-oxidized abasic sites (DOB) that are produced following hydrogen atom abstraction from the DNA backbone were found to produce ICLs. Be...

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Detalhes bibliográficos
Main Authors: Ghosh, Souradyuti, Greenberg, Marc M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2014
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4172206/
https://ncbi.nlm.nih.gov/pubmed/25208227
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi500914d
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