Transcriptional silencing by single-stranded RNAs targeting a noncoding RNA that overlaps a gene promoter

Por Matsui, Masayuki, Prakash, Thazha P., Corey, David R.
Publicado em 2012

Argonaute 2-dependent Regulation of Gene Expression by Single-stranded miRNA Mimics

Por Matsui, Masayuki, Prakash, Thazha P, Corey, David R
Publicado no Mol Ther (2016)

Recognition of c9orf72 Mutant RNA by Single-Stranded Silencing RNAs

Por Hu, Jiaxin, Rigo, Frank, Prakash, Thazha P., Corey, David R.
Publicado no Nucleic Acid Ther (2017)

TCP1 complex proteins interact with phosphorothioate oligonucleotides and can co-localize in oligonucleotide-induced nuclear bodies in mammalian cells

Por Liang, Xue-hai, Shen, Wen, Sun, Hong, Prakash, Thazha P., Crooke, Stanley T.
Publicado em 2014

Stabilizing contributions of sulfur-modified nucleotides: crystal structure of a DNA duplex with 2′-O-[2-(methoxy)ethyl]-2-thiothymidines

Por Diop-Frimpong, Benjamin, Prakash, Thazha P., Rajeev, Kallanthottathil G., Manoharan, Muthiah, Egli, Martin
Publicado em 2005

Modulation of Splicing by Single-Stranded Silencing RNAs

Por Liu, Jing, Hu, Jiaxin, Hicks, Jessica A., Prakash, Thazha P., Corey, David R.
Publicado no Nucleic Acid Ther (2015)

2′-O-[2-[(N,N-dimethylamino)oxy]ethyl]-modified oligonucleotides inhibit expression of mRNA in vitro and in vivo

Por Prakash, Thazha P., Johnston, Joseph F., Graham, Mark J., Condon, Thomas P., Manoharan, Muthiah
Publicado em 2004

A Conformational Transition in the Structure of a 2′-Thiomethyl-Modified DNA Visualized at High Resolution

Por Pallan, Pradeep S., Prakash, Thazha P., Li, Feng, Eoff, Robert L., Manoharan, Muthiah, Egli, Martin
Publicado em 2009

2′-Fluoroarabino- and Arabinonucleic Acid Show Different Conformations, Resulting in Deviating RNA Affinities and Processing of Their Heteroduplexes with RNA by RNase H

Por Li, Feng, Sarkhel, Sanjay, Wilds, Christopher J., Wawrzak, Zdzislaw, Prakash, Thazha P., Manoharan, Muthiah, Egli, Martin
Publicado em 2006

Synthetic oligonucleotides recruit ILF2/3 to RNA transcripts to modulate splicing

Por Rigo, Frank, Hua, Yimin, Chun, Seung J, Prakash, Thazha P, Krainer, Adrian R, Bennett, C Frank
Publicado no Nat Chem Biol (2012)

Structure and Nuclease Resistance of 2′,4′-Constrained 2′-O-Methoxyethyl (cMOE) and 2′-O-Ethyl (cEt) Modified DNAs

Por Pallan, Pradeep S., Allerson, Charles R., Berdeja, Andres, Seth, Punit P., Swayze, Eric E., Prakash, Thazha P., Egli, Martin
Publicado em 2012

Synthetic CRISPR RNA-Cas9–guided genome editing in human cells

Por Rahdar, Meghdad, McMahon, Moira A., Prakash, Thazha P., Swayze, Eric E., Bennett, C. Frank, Cleveland, Don W.
Publicado no Proc Natl Acad Sci U S A (2015)

Hsp90 protein interacts with phosphorothioate oligonucleotides containing hydrophobic 2′-modifications and enhances antisense activity

Por Liang, Xue-Hai, Shen, Wen, Sun, Hong, Kinberger, Garth A., Prakash, Thazha P., Nichols, Joshua G., Crooke, Stanley T.
Publicado no Nucleic Acids Res (2016)

Structural analysis of human Argonaute-2 bound to a modified siR-NA guide

Por Schirle, Nicole T., Kinberger, Garth A., Murray, Heather F., Lima, Walt F., Prakash, Thazha P., MacRae, Ian J.
Publicado no J Am Chem Soc (2016)

ss-siRNAs allele selectively inhibit ataxin-3 expression: multiple mechanisms for an alternative gene silencing strategy

Por Liu, Jing, Yu, Dongbo, Aiba, Yuichiro, Pendergraff, Hannah, Swayze, Eric E., Lima, Walt F., Hu, Jiaxin, Prakash, Thazha P., Corey, David R.
Publicado em 2013

An Exocyclic Methylene Group Acts As A Bio-isostere of the 2’-Oxygen Atom in LNA

Por Seth, Punit P, Allerson, Charles R., Berdeja, Andres, Siwkowski, Andrew, Pallan, Pradeep S., Gaus, Hans, Prakash, Thazha P., Watt, Andrew T., Egli, Martin, Swayze, Eric E.
Publicado em 2010

TricycloDNA-modified oligo-2′-deoxyribonucleotides reduce scavenger receptor B1 mRNA in hepatic and extra-hepatic tissues—a comparative study of oligonucleotide length, design and...

Por Murray, Sue, Ittig, Damian, Koller, Erich, Berdeja, Andres, Chappell, Alfred, Prakash, Thazha P., Norrbom, Michaela, Swayze, Eric E., Leumann, Christian J., Seth, Punit P.
Publicado em 2012

Single-Stranded RNAs Use RNAi to Potently and Allele-Selectively Inhibit Mutant Huntingtin Expression

Por Yu, Dongbo, Pendergraff, Hannah, Liu, Jing, Kordasiewicz, Holly B., Cleveland, Don W., Swayze, Eric E., Lima, Walt F., Crooke, Stanley T., Prakash, Thazha P., Corey, David R.
Publicado em 2012

Characterizing the effect of GalNAc and phosphorothioate backbone on binding of antisense oligonucleotides to the asialoglycoprotein receptor

Por Schmidt, Karsten, Prakash, Thazha P., Donner, Aaron J., Kinberger, Garth A., Gaus, Hans J., Low, Audrey, Østergaard, Michael E., Bell, Melanie, Swayze, Eric E., Seth, Punit P.
Publicado no Nucleic Acids Res (2017)

Synthesis, Improved Antisense Activity and Structural Rationale for the Divergent RNA Affinities of 3′-Fluoro Hexitol Nucleic Acid (FHNA and Ara-FHNA) Modified Oligonucleotides

Por Egli, Martin, Pallan, Pradeep S., Allerson, Charles R., Prakash, Thazha P., Berdeja, Andres, Yu, Jinghua, Lee, Sam, Watt, Andrew, Gaus, Hans, Bhat, Balkrishen, Swayze, Eric E., Seth, Punit P.
Publicado em 2011