Synthesis, Duplex Stabilization and Structural Properties of a Fluorinated Carbocyclic LNA Analog

Por Seth, Punit P., Pallan, Pradeep S., Swayze, Eric E., Egli, Martin
Publicado em 2012

Insights from Crystal Structures into the Opposite Effects on RNA Affinity by the S- and R-6′-Methyl Backbone Modifications of 3′-Fluoro Hexitol Nucleic Acid (FHNA)()

Por Pallan, Pradeep S., Yu, Jinghua, Allerson, Charles R., Swayze, Eric E., Seth, Punit, Egli, Martin
Publicado em 2011

Structure Activity Relationships of α-L-LNA Modified Phosphorothioate Gapmer Antisense Oligonucleotides in Animals

Por Seth, Punit P, Jazayeri, Ali, Yu, Jeff, Allerson, Charles R, Bhat, Balkrishen, Swayze, Eric E
Publicado em 2012

Structure and Nuclease Resistance of 2′,4′-Constrained 2′-O-Methoxyethyl (cMOE) and 2′-O-Ethyl (cEt) Modified DNAs

Por Pallan, Pradeep S., Allerson, Charles R., Berdeja, Andres, Seth, Punit P., Swayze, Eric E., Prakash, Thazha P., Egli, Martin
Publicado em 2012

Synthetic CRISPR RNA-Cas9–guided genome editing in human cells

Por Rahdar, Meghdad, McMahon, Moira A., Prakash, Thazha P., Swayze, Eric E., Bennett, C. Frank, Cleveland, Don W.
Publicado no Proc Natl Acad Sci U S A (2015)

Fluorinated Nucleotide Modifications Modulate Allele Selectivity of SNP-Targeting Antisense Oligonucleotides

Por Østergaard, Michael E., Nichols, Josh, Dwight, Timothy A., Lima, Walt, Jung, Michael E., Swayze, Eric E., Seth, Punit P.
Publicado no Mol Ther Nucleic Acids (2017)

Inhibitor-induced structural change in the HCV IRES domain IIa RNA

Por Paulsen, Ryan B., Seth, Punit P., Swayze, Eric E., Griffey, Richard H., Skalicky, Jack J., Cheatham, Thomas E., Davis, Darrell R.
Publicado em 2010

Antisense oligonucleotides containing locked nucleic acid improve potency but cause significant hepatotoxicity in animals

Por Swayze, Eric E., Siwkowski, Andrew M., Wancewicz, Edward V., Migawa, Michael T., Wyrzykiewicz, Tadeusz K., Hung, Gene, Monia, Brett P., Bennett, and C. Frank
Publicado em 2007

ss-siRNAs allele selectively inhibit ataxin-3 expression: multiple mechanisms for an alternative gene silencing strategy

Por Liu, Jing, Yu, Dongbo, Aiba, Yuichiro, Pendergraff, Hannah, Swayze, Eric E., Lima, Walt F., Hu, Jiaxin, Prakash, Thazha P., Corey, David R.
Publicado em 2013

An Exocyclic Methylene Group Acts As A Bio-isostere of the 2’-Oxygen Atom in LNA

Por Seth, Punit P, Allerson, Charles R., Berdeja, Andres, Siwkowski, Andrew, Pallan, Pradeep S., Gaus, Hans, Prakash, Thazha P., Watt, Andrew T., Egli, Martin, Swayze, Eric E.
Publicado em 2010

TricycloDNA-modified oligo-2′-deoxyribonucleotides reduce scavenger receptor B1 mRNA in hepatic and extra-hepatic tissues—a comparative study of oligonucleotide length, design and...

Por Murray, Sue, Ittig, Damian, Koller, Erich, Berdeja, Andres, Chappell, Alfred, Prakash, Thazha P., Norrbom, Michaela, Swayze, Eric E., Leumann, Christian J., Seth, Punit P.
Publicado em 2012

Synthesis and Antisense Properties of Fluoro Cyclohexenyl Nucleic Acid (F-CeNA) – A Nuclease Stable Mimic of 2′-Fluoro RNA

Por Seth, Punit P., Yu, Jinghua, Jazayeri, Ali, Pallan, Pradeep S., Allerson, Charles R, Østergaard, Michael E., Liu, Fengwu, Herdewijn, Piet, Egli, Martin, Swayze, Eric E.
Publicado em 2012

Competition for RISC binding predicts in vitro potency of siRNA

Por Koller, Erich, Propp, Stephanie, Murray, Heather, Lima, Walter, Bhat, Balkrishen, Prakash, Thaza P., Allerson, Charles R., Swayze, Eric E., Marcusson, Eric G., Dean, Nicholas M.
Publicado em 2006

Potent inhibition of microRNA in vivo without degradation

Por Davis, Scott, Propp, Stephanie, Freier, Susan M., Jones, Laura E., Serra, Martin J., Kinberger, Garth, Bhat, Balkrishen, Swayze, Eric E., Bennett, C. Frank, Esau, Christine
Publicado em 2009

Allele-selective inhibition of ataxin-3 (ATX3) expression by antisense oligomers and duplex RNAs

Por Hu, Jiaxin, Gagnon, Keith T., Liu, Jing, Watts, Jonathan K., Syeda-Nawaz, Jeja, Bennett, C. Frank, Swayze, Eric E., Randolph, John, Chattopadhyaya, Jyoti, Corey, David R.
Publicado em 2011

Single-Stranded RNAs Use RNAi to Potently and Allele-Selectively Inhibit Mutant Huntingtin Expression

Por Yu, Dongbo, Pendergraff, Hannah, Liu, Jing, Kordasiewicz, Holly B., Cleveland, Don W., Swayze, Eric E., Lima, Walt F., Crooke, Stanley T., Prakash, Thazha P., Corey, David R.
Publicado em 2012

Characterizing the effect of GalNAc and phosphorothioate backbone on binding of antisense oligonucleotides to the asialoglycoprotein receptor

Por Schmidt, Karsten, Prakash, Thazha P., Donner, Aaron J., Kinberger, Garth A., Gaus, Hans J., Low, Audrey, Østergaard, Michael E., Bell, Melanie, Swayze, Eric E., Seth, Punit P.
Publicado no Nucleic Acids Res (2017)

Synthesis, Improved Antisense Activity and Structural Rationale for the Divergent RNA Affinities of 3′-Fluoro Hexitol Nucleic Acid (FHNA and Ara-FHNA) Modified Oligonucleotides

Por Egli, Martin, Pallan, Pradeep S., Allerson, Charles R., Prakash, Thazha P., Berdeja, Andres, Yu, Jinghua, Lee, Sam, Watt, Andrew, Gaus, Hans, Bhat, Balkrishen, Swayze, Eric E., Seth, Punit P.
Publicado em 2011

Identification of metabolically stable 5′-phosphate analogs that support single-stranded siRNA activity

Por Prakash, Thazha P., Lima, Walt F., Murray, Heather M., Li, Wenyu, Kinberger, Garth A., Chappell, Alfred E., Gaus, Hans, Seth, Punit P., Bhat, Balkrishen, Crooke, Stanley T., Swayze, Eric E.
Publicado no Nucleic Acids Res (2015)

Synthesis, biophysical properties and biological activity of second generation antisense oligonucleotides containing chiral phosphorothioate linkages

Por Wan, W. Brad, Migawa, Michael T., Vasquez, Guillermo, Murray, Heather M., Nichols, Josh G., Gaus, Hans, Berdeja, Andres, Lee, Sam, Hart, Christopher E., Lima, Walt F., Swayze, Eric E., Seth, Punit P.
Publicado no Nucleic Acids Res (2014)