Pyrene-functionalized oligonucleotides and locked nucleic acids (LNAs): Tools for fundamental research, diagnostics, and materials science()

av Østergaard, Michael E., Hrdlicka, Patrick J.
Publicerad 2011

Functionalized 2′-Amino-α-L-LNA - Directed Positioning of Intercalators for DNA Targeting

av Kumar, T. Santhosh, Madsen, Andreas S., Østergaard, Michael E., Sau, Sujay P., Wengel, Jesper, Hrdlicka, Patrick J.
Publicerad 2009

Characterization of the interactions of chemically-modified therapeutic nucleic acids with plasma proteins using a fluorescence polarization assay

av Gaus, Hans J, Gupta, Ruchi, Chappell, Alfred E, Østergaard, Michael E, Swayze, Eric E, Seth, Punit P
I publikationen Nucleic Acids Res (2019)

C5-Alkynyl-Functionalized α-L-LNA: Synthesis, Thermal Denaturation Experiments and Enzymatic Stability

av Kumar, Pawan, Baral, Bharat, Anderson, Brooke A., Guenther, Dale C., Østergaard, Michael E., Sharma, Pawan K., Hrdlicka, Patrick J.
Publicerad 2014

Fluorinated Nucleotide Modifications Modulate Allele Selectivity of SNP-Targeting Antisense Oligonucleotides

av Østergaard, Michael E., Nichols, Josh, Dwight, Timothy A., Lima, Walt, Jung, Michael E., Swayze, Eric E., Seth, Punit P.
I publikationen Mol Ther Nucleic Acids (2017)

Optimized DNA-targeting using triplex forming C5-alkynyl functionalized LNA

av Sau, Sujay P., Kumar, Pawan, Anderson, Brooke A., Østergaard, Michael E., Deobald, Lee, Paszczynski, Andrzej, Sharma, Pawan K., Hrdlicka, Patrick J.
Publicerad 2009

Synthesis and Antisense Properties of Fluoro Cyclohexenyl Nucleic Acid (F-CeNA) – A Nuclease Stable Mimic of 2′-Fluoro RNA

av Seth, Punit P., Yu, Jinghua, Jazayeri, Ali, Pallan, Pradeep S., Allerson, Charles R, Østergaard, Michael E., Liu, Fengwu, Herdewijn, Piet, Egli, Martin, Swayze, Eric E.
Publicerad 2012

Synthesis and Biophysical Properties of C5-Functionalized LNA (Locked Nucleic Acid)

av Kumar, Pawan, Østergaard, Michael E., Baral, Bharat, Anderson, Brooke A., Guenther, Dale C., Kaura, Mamta, Raible, Daniel J., Sharma, Pawan K., Hrdlicka, Patrick J.
Publicerad 2014

Stabilin-1 and Stabilin-2 are specific receptors for the cellular internalization of phosphorothioate-modified antisense oligonucleotides (ASOs) in the liver

av Miller, Colton M., Donner, Aaron J., Blank, Emma E., Egger, Andrew W., Kellar, Brianna M., Østergaard, Michael E., Seth, Punit P., Harris, Edward N.
I publikationen Nucleic Acids Res (2016)

Characterizing the effect of GalNAc and phosphorothioate backbone on binding of antisense oligonucleotides to the asialoglycoprotein receptor

av Schmidt, Karsten, Prakash, Thazha P., Donner, Aaron J., Kinberger, Garth A., Gaus, Hans J., Low, Audrey, Østergaard, Michael E., Bell, Melanie, Swayze, Eric E., Seth, Punit P.
I publikationen Nucleic Acids Res (2017)

Fatty acid conjugation enhances potency of antisense oligonucleotides in muscle

av Prakash, Thazha P, Mullick, Adam E, Lee, Richard G, Yu, Jinghua, Yeh, Steve T, Low, Audrey, Chappell, Alfred E, Østergaard, Michael E, Murray, Sue, Gaus, Hans J, Swayze, Eric E, Seth, Punit P
I publikationen Nucleic Acids Res (2019)

Rational design of antisense oligonucleotides targeting single nucleotide polymorphisms for potent and allele selective suppression of mutant Huntingtin in the CNS

av Østergaard, Michael E., Southwell, Amber L., Kordasiewicz, Holly, Watt, Andrew T., Skotte, Niels H., Doty, Crystal N., Vaid, Kuljeet, Villanueva, Erika B., Swayze, Eric E., Frank Bennett, C., Hayden, Michael R., Seth, Punit P.
Publicerad 2013

Understanding the effect of controlling phosphorothioate chirality in the DNA gap on the potency and safety of gapmer antisense oligonucleotides

av Østergaard, Michael E, De Hoyos, Cheryl L, Wan, W Brad, Shen, Wen, Low, Audrey, Berdeja, Andres, Vasquez, Guillermo, Murray, Susan, Migawa, Michael T, Liang, Xue-hai, Swayze, Eric E, Crooke, Stanley T, Seth, Punit P
I publikationen Nucleic Acids Res (2020)

Site-specific incorporation of 5′-methyl DNA enhances the therapeutic profile of gapmer ASOs

av Vasquez, Guillermo, Freestone, Graeme C, Wan, W Brad, Low, Audrey, De Hoyos, Cheryl Li, Yu, Jinghua, Prakash, Thazha P, Ǿstergaard, Michael E, Liang, Xue-hai, Crooke, Stanley T, Swayze, Eric E, Migawa, Michael T, Seth, Punit P
I publikationen Nucleic Acids Res (2021)

HD iPSC-derived neural progenitors accumulate in culture and are susceptible to BDNF withdrawal due to glutamate toxicity

av Mattis, Virginia B., Tom, Colton, Akimov, Sergey, Saeedian, Jasmine, Østergaard, Michael E., Southwell, Amber L., Doty, Crystal N., Ornelas, Loren, Sahabian, Anais, Lenaeus, Lindsay, Mandefro, Berhan, Sareen, Dhruv, Arjomand, Jamshid, Hayden, Michael R., Ross, Christopher A., Svendsen, Clive N.
I publikationen Hum Mol Genet (2015)

Allele-Specific Suppression of Mutant Huntingtin Using Antisense Oligonucleotides: Providing a Therapeutic Option for All Huntington Disease Patients

av Skotte, Niels H., Southwell, Amber L., Østergaard, Michael E., Carroll, Jeffrey B., Warby, Simon C., Doty, Crystal N., Petoukhov, Eugenia, Vaid, Kuljeet, Kordasiewicz, Holly, Watt, Andrew T., Freier, Susan M., Hung, Gene, Seth, Punit P., Bennett, C. Frank, Swayze, Eric E., Hayden, Michael R.
Publicerad 2014

In Vivo Evaluation of Candidate Allele-specific Mutant Huntingtin Gene Silencing Antisense Oligonucleotides

av Southwell, Amber L, Skotte, Niels H, Kordasiewicz, Holly B, Østergaard, Michael E, Watt, Andrew T, Carroll, Jeffrey B, Doty, Crystal N, Villanueva, Erika B, Petoukhov, Eugenia, Vaid, Kuljeet, Xie, Yuanyun, Freier, Susan M, Swayze, Eric E, Seth, Punit P, Bennett, Clarence Frank, Hayden, Michael R
I publikationen Mol Ther (2014)

Conjugation of hydrophobic moieties enhances potency of antisense oligonucleotides in the muscle of rodents and non-human primates

av Østergaard, Michael E, Jackson, Michaela, Low, Audrey, E. Chappell, Alfred, G. Lee, Richard, Peralta, Rachel Q, Yu, Jinghua, Kinberger, Garth A, Dan, Amy, Carty, Rick, Tanowitz, Michael, Anderson, Patrick, Kim, Tae-Won, Fradkin, Linda, Mullick, Adam E, Murray, Sue, Rigo, Frank, Prakash, Thazha P, Bennett, C Frank, Swayze, Eric E, Gaus, Hans J, Seth, Punit P
I publikationen Nucleic Acids Res (2019)