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Functionalized 2′-Amino-α-L-LNA - Directed Positioning of Intercalators for DNA Targeting
Chemically modified oligonucleotides are increasingly applied in nucleic acid based therapeutics and diagnostics. LNA (Locked Nucleic Acid) and its diastereomer α-L-LNA are two promising examples hereof that exhibit increased thermal and enzymatic stability. Herein, the synthesis, biophysical charac...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2853939/ https://ncbi.nlm.nih.gov/pubmed/19108636 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jo802037v |
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