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Synthesis and Characterization of Oligodeoxyribonucleotides Modified with 2′-Amino-α-L-LNA Adenine Monomers: High-affinity Targeting of Single-Stranded DNA

[Image: see text] Development of conformationally restricted nucleotide building blocks continues to attract considerable interest due to their successful use within antisense, antigene and other gene-targeting strategies. Locked nucleic acid (LNA) and its diastereomer α-L-LNA are two interesting ex...

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Detalhes bibliográficos
Main Authors: Andersen, Nicolai K., Anderson, Brooke A., Wengel, Jesper, Hrdlicka, Patrick J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3914402/
https://ncbi.nlm.nih.gov/pubmed/24304240
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jo4022937
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