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Optimized DNA-targeting using triplex forming C5-alkynyl functionalized LNA

Triplex forming oligonucleotides (TFOs) modified with C5-alkynyl functionalized LNA (locked nucleic acid) monomers display extraordinary thermal affinity toward double stranded DNA targets, excellent discrimination of Hoogsteen-mismatched targets, and high stability against 3′-exonucleases.

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Bibliografiske detaljer
Main Authors: Sau, Sujay P., Kumar, Pawan, Anderson, Brooke A., Østergaard, Michael E., Deobald, Lee, Paszczynski, Andrzej, Sharma, Pawan K., Hrdlicka, Patrick J.
Format: Artigo
Sprog:Inglês
Udgivet: 2009
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2846108/
https://ncbi.nlm.nih.gov/pubmed/19885469
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/b917312a
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