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Optimized DNA-targeting using triplex forming C5-alkynyl functionalized LNA
Triplex forming oligonucleotides (TFOs) modified with C5-alkynyl functionalized LNA (locked nucleic acid) monomers display extraordinary thermal affinity toward double stranded DNA targets, excellent discrimination of Hoogsteen-mismatched targets, and high stability against 3′-exonucleases.
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| Autori principali: | , , , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2009
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2846108/ https://ncbi.nlm.nih.gov/pubmed/19885469 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/b917312a |
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