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Synthesis and Excellent Duplex Stability of Oligonucleotides Containing 2′-Amino-LNA Functionalized with Galactose Units

A convenient method for the preparation of oligonucleotides containing internally-attached galactose and triantennary galactose units has been developed based on click chemistry between 2′-N-alkyne 2′-amino-LNA nucleosides and azido-functionalized galactosyl building blocks. The synthesized oligonuc...

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Detalhes bibliográficos
Publicado no:Molecules
Main Authors: Kumar, Rajesh, Ries, Annika, Wengel, Jesper
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6153924/
https://ncbi.nlm.nih.gov/pubmed/28531137
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules22050852
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