Stopped-flow kinetics of locked nucleic acid (LNA)-oligonucleotide duplex formation: studies of LNA-DNA and DNA-DNA interactions.

The locked nucleic acid (LNA) monomer is a conformationally restricted nucleotide analogue with an extra 2'-O,4'-C-methylene bridge added to the ribose ring. Oligonucleotides that contain LNA monomers have shown greatly enhanced thermal stability when hybridized to complementary DNA and RN...

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Main Authors: Christensen, U, Jacobsen, N, Rajwanshi, V K, Wengel, J, Koch, T
Formato: Artigo
Idioma:Inglês
Publicado: 2001
Assuntos:
Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC1221678/
https://ncbi.nlm.nih.gov/pubmed/11237851
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