Development of bis-locked nucleic acid (bisLNA) oligonucleotides for efficient invasion of supercoiled duplex DNA

In spite of the many developments in synthetic oligonucleotide (ON) chemistry and design, invasion into double-stranded DNA (DSI) under physiological salt and pH conditions remains a challenge. In this work, we provide a new ON tool based on locked nucleic acids (LNAs), designed for strand invasion...

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Bibliografische gegevens
Hoofdauteurs: Moreno, Pedro M. D., Geny, Sylvain, Pabon, Y. Vladimir, Bergquist, Helen, Zaghloul, Eman M., Rocha, Cristina S. J., Oprea, Iulian I., Bestas, Burcu, Andaloussi, Samir EL, Jørgensen, Per T., Pedersen, Erik B., Lundin, Karin E., Zain, Rula, Wengel, Jesper, Smith, C. I. Edvard
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Oxford University Press 2013
Onderwerpen:
Molecular Biology
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3597675/
https://ncbi.nlm.nih.gov/pubmed/23345620
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkt007
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