Development of bis-locked nucleic acid (bisLNA) oligonucleotides for efficient invasion of supercoiled duplex DNA

In spite of the many developments in synthetic oligonucleotide (ON) chemistry and design, invasion into double-stranded DNA (DSI) under physiological salt and pH conditions remains a challenge. In this work, we provide a new ON tool based on locked nucleic acids (LNAs), designed for strand invasion...

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書誌詳細
主要な著者: Moreno, Pedro M. D., Geny, Sylvain, Pabon, Y. Vladimir, Bergquist, Helen, Zaghloul, Eman M., Rocha, Cristina S. J., Oprea, Iulian I., Bestas, Burcu, Andaloussi, Samir EL, Jørgensen, Per T., Pedersen, Erik B., Lundin, Karin E., Zain, Rula, Wengel, Jesper, Smith, C. I. Edvard
フォーマット: Artigo
言語:Inglês
出版事項: Oxford University Press 2013
主題:
Molecular Biology
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3597675/
https://ncbi.nlm.nih.gov/pubmed/23345620
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkt007
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